The research team examined the RNA encoding a protein called “coatomer subunit α” (COPA), which influences the development of cancers of the liver, esophagus, stomach and breast, and examined whether RNA transcribed from the COPA gene was edited or altered in clinical samples of cancerous liver tissues. They discovered that any given cell contains a mix of both edited and unedited versions of COPA. When the unedited or “wild type” COPA is predominant, the cell is more likely to become cancerous. Conversely, when edited COPA is predominant, it is thought to suppress a convoluted molecular signalling network called the PI3K/AKT/mTOR signalling pathway. When this pathway gets out of control, it triggers excessive cell multiplication which can lead to cancer.

Their findings were first published in the scientific journal, the Journal of Hepatology, on 18 July 2020.

The researchers are now trying to find a way to boost the natural RNA editing mechanisms in the cancerous cell to tip the balance in favour of the edited version of COPA, thereby suppressing the cancer.

“With this new knowledge, we can now look into how A-to-I RNA editing contributes to cancer by altering their protein sequences and how we can restore cancer-suppressing processes mediated by RNA editing in the cell,” said Dr Chen.

Previous LTA To Deploy Three-Door Double-Deck Buses From 2021
Next Grab And Panasonic Launch Integrated Campaign To Promote Better Indoor Air Quality In Southeast Asia

Suggested Posts

Establishment Of Operational Technology Cybersecurity Expert Panel

Joint Ventures Between Allgreen Properties Ltd And Kerry Properties Ltd Secure S$861.75 Million Green Loan From DBS, Maybank And OCBC Bank

Innovfest Unbound Connects Southeast Asia’s Top Startups With Leading Global Corporations

DBS Launches Asia’s First Automated Digital Bond Issuance Platform