The research team examined the RNA encoding a protein called “coatomer subunit α” (COPA), which influences the development of cancers of the liver, esophagus, stomach and breast, and examined whether RNA transcribed from the COPA gene was edited or altered in clinical samples of cancerous liver tissues. They discovered that any given cell contains a mix of both edited and unedited versions of COPA. When the unedited or “wild type” COPA is predominant, the cell is more likely to become cancerous. Conversely, when edited COPA is predominant, it is thought to suppress a convoluted molecular signalling network called the PI3K/AKT/mTOR signalling pathway. When this pathway gets out of control, it triggers excessive cell multiplication which can lead to cancer.

Their findings were first published in the scientific journal, the Journal of Hepatology, on 18 July 2020.

The researchers are now trying to find a way to boost the natural RNA editing mechanisms in the cancerous cell to tip the balance in favour of the edited version of COPA, thereby suppressing the cancer.

“With this new knowledge, we can now look into how A-to-I RNA editing contributes to cancer by altering their protein sequences and how we can restore cancer-suppressing processes mediated by RNA editing in the cell,” said Dr Chen.

Previous LTA To Deploy Three-Door Double-Deck Buses From 2021
Next Grab And Panasonic Launch Integrated Campaign To Promote Better Indoor Air Quality In Southeast Asia

Suggested Posts

NEA Launches A New Campaign Urging Residents To Sustain Dengue Prevention Efforts During The Year-End Holiday Season, To Prevent A Second Dengue Peak This Year

How Conscious Consumerism Is Taking Root In India

Surbana Jurong And NTU Singapore To Develop Hybrid System To Deliver Cleaner And More Sustainable Energy From LNG

GovTech Licenses “SPOTON” Software To SMEs & NPO To Produce Smart Thermal Scanners