dotlah! dotlah!
  • Cities
  • Technology
  • Business
  • Politics
  • Society
  • Science
  • About
Social Links
  • zedreviews.com
  • citi.io
  • aster.cloud
  • liwaiwai.com
  • guzz.co.uk
  • atinatin.com
0 Likes
0 Followers
0 Subscribers
dotlah!
  • Cities
  • Technology
  • Business
  • Politics
  • Society
  • Science
  • About
  • Lah!
  • Science

NUS Scientists Find New Mechanism Of Cancer Formation

  • January 15, 2021
Total
0
Shares
0
0
0

A team of NUS scientists led by Dr Polly Leilei Chen from the Cancer Science Institute of Singapore and Yong Loo Lin School of Medicine has discovered a previously unknown mechanism of cancer formation, the understanding of which may lead to more effective treatment.

Their findings concern a process called RNA editing. The DNA code of a gene gets transcribed into an intermediate code known as RNA, before being translated into a protein molecule that plays a particular role in the cell. Sometimes, the RNA gets modified, or edited, before the final translation, yielding a different protein product. RNA editing is a phenomenon that gives the cell finer control over its proteins.

2021-01-14 CSI cancer formation 1
The novel mechanism of cancer formation discovered by Dr Polly Leilei Chen (right), Dr Song Yangyang (left) and their team could lead to more effective treatment.

The research team examined the RNA encoding a protein called “coatomer subunit α” (COPA), which influences the development of cancers of the liver, esophagus, stomach and breast, and examined whether RNA transcribed from the COPA gene was edited or altered in clinical samples of cancerous liver tissues. They discovered that any given cell contains a mix of both edited and unedited versions of COPA. When the unedited or “wild type” COPA is predominant, the cell is more likely to become cancerous. Conversely, when edited COPA is predominant, it is thought to suppress a convoluted molecular signalling network called the PI3K/AKT/mTOR signalling pathway. When this pathway gets out of control, it triggers excessive cell multiplication which can lead to cancer.

Their findings were first published in the scientific journal, the Journal of Hepatology, on 18 July 2020.

The researchers are now trying to find a way to boost the natural RNA editing mechanisms in the cancerous cell to tip the balance in favour of the edited version of COPA, thereby suppressing the cancer.

“With this new knowledge, we can now look into how A-to-I RNA editing contributes to cancer by altering their protein sequences and how we can restore cancer-suppressing processes mediated by RNA editing in the cell,” said Dr Chen.

Total
0
Shares
Share
Tweet
Share
Share
Related Topics
  • Cancer
  • Cancer Science Institure of Singapore
  • National University of Singapore
  • NUS
dotlah.com

Previous Article
  • Cities
  • Lah!

LTA To Deploy Three-Door Double-Deck Buses From 2021

  • January 14, 2021
View Post
Next Article
  • Cities
  • Lah!

Grab And Panasonic Launch Integrated Campaign To Promote Better Indoor Air Quality In Southeast Asia

  • January 15, 2021
View Post
You May Also Like
View Post
  • Lah!

Tariffs, Trump, and Other Things That Start With T – They’re Not The Problem, It’s How We Use Them

  • John Francis
  • March 25, 2025
View Post
  • Lah!

Canonical announces 12 year Kubernetes LTS

  • John Francis
  • March 4, 2025
dotlah-smartnation-singapore-lawrence-wong
View Post
  • Artificial Intelligence
  • Featured
  • Features
  • Lah!
  • Machine Learning
  • Technology

Growth, community and trust the ‘building blocks’ as Singapore refreshes Smart Nation strategies: PM Wong

  • Dean Marc
  • October 9, 2024
dotlah-singapore-ndp-2024
View Post
  • Lah!

Here’s what to expect for NDP 2024!

  • dotlah.com
  • August 9, 2024
dotlah-singapore-airlines_may_21-1716298816
View Post
  • Lah!

Severe turbulence during Singapore Airlines flight leaves several people badly injured. One man died

  • majulah
  • May 22, 2024
dotlah-pm-lee-lawrence-wong-9656d4cd-1fa4-40ed-905d-e19e639b8476_728802dd
View Post
  • Lah!
  • People
  • Politics

End of Lee Era for Singapore as PM Steps Down

  • dotlah.com
  • May 16, 2024
DPM Lawrence Wong will be Singapore's fourth prime minister on May 15. ST PHOTO: LIM YAOHUI
View Post
  • Lah!
  • People
  • Politics

7 things to know about Singapore’s next prime minister Lawrence Wong

  • dotlah.com
  • May 15, 2024
When asked about his leadership style, DPM Lawrence Wong said he will be open and consultative, but he will not shirk from doing what is necessary for Singapore's future. ST PHOTO: LIM YAOHUI
View Post
  • Features
  • Lah!
  • People
  • Politics

‘We are prepared to relook everything’: Lawrence Wong on a changing society and his hopes for S’pore

  • dotlah.com
  • May 15, 2024


Trending
  • 1
    • Lah!
    • Science
    New Crab Species With Asymmetrical Reproductive Units Identified
    • June 22, 2021
  • 2
    • Society
    Coronavirus: The Latest Disease To Fuel Mistrust, Fear And Racism
    • February 13, 2020
  • 3
    • Lah!
    • Science
    Top 10 Must-See Museums In Singapore
    • December 23, 2019
  • iceland-landon-arnold-MgWEUyCU0rs-unsplash 4
    • Cities
    • World Events
    How To Build More Resilient Countries After The COVID-19 Pandemic
    • February 16, 2021
  • 5
    • Cities
    DBS Named Asia’s Safest Bank For 12th Consecutive Year
    • October 21, 2020
  • 6
    • Technology
    Singtel’s Dash Partners UOB Asset Management To Offer Mobile Robo-Adviser With Exclusive ESG Option
    • December 22, 2021
  • london-crowd-viktor-forgacs-6bMyJEvr-Cw-unsplash 7
    • Cities
    • Economy
    The World’s Next Megacities
    • January 20, 2023
  • 8
    • Cities
    • Lah!
    • Society
    NUS Computing Establishes Sea Olympiad Scholarship To Attract And Nurture Top Talents In Computer Studies
    • February 27, 2022
  • 9
    • Cities
    SUTD Announces Multi-Faceted Sustainability Plan For A More Sustainable And Happier World By Design
    • December 7, 2021
  • First IBM Quantum Data Center in Europe Opens 10
    • Computing
    • Technology
    First IBM Quantum Data Center In Europe Opens; Will Include Ibm’s Most Performant Quantum Systems
    • October 1, 2024
  • 11
    • Technology
    The Dream Of Living On Other Worlds
    • July 15, 2019
  • 12
    • Society
    FairPrice Group Pledges S$378,000 To Engage The Community To Do Good And Provides Incentives To Appreciate Healthcare Workers
    • March 6, 2020
Trending
  • French Fries 1
    Air Fryer: The One Cooking Appliance to Rule Them All – Best All-Around Picks in 2025
    • August 22, 2025
  • 2
    Samsung Electronics Debuts Odyssey G7 Monitors, Showcasing Top Games on Its Displays at Gamescom 2025
    • August 20, 2025
  • 3
    HP Cranks Up the Game with Smarter Systems, Cooler Builds, and Gear That Hits Different
    • August 14, 2025
  • 4
    New Trump tariffs: early modelling shows most economies lose – the US more than many
    • August 6, 2025
  • Scuba Diving 5
    Wetsuit or Drysuit? As always, it depends. This quick guide can help you choose.
    • August 2, 2025
  • 6
    Thoughts on America’s AI Action Plan
    • July 24, 2025
  • 7
    Introducing Surface Laptop 5G: Seamless connectivity, built for business
    • July 23, 2025
  • 8
    Press Start (Or Hit Enter)! Your Go-To Loadout for Streamers and Gamers.
    • July 19, 2025
  • 9
    ESWIN Computing launches the EBC77 Series Single Board Computer with Ubuntu
    • July 17, 2025
  • 10
    Samsung Galaxy Z Fold7: Raising the Bar for Smartphones
    • July 9, 2025
Social Links
dotlah! dotlah!
  • Cities
  • Technology
  • Business
  • Politics
  • Society
  • Science
  • About
Connecting Dots Across Asia's Tech and Urban Landscape

Input your search keywords and press Enter.